Total synthesis of ent-dioxepandehydrothyrsiferol via a bromonium-initiated epoxide-opening cascade.

نویسندگان

  • Jessica Tanuwidjaja
  • Sze-Sze Ng
  • Timothy F Jamison
چکیده

In the first total synthesis of ent-dioxepandehydrothyrsiferol, the signature trans-anti-trans 7,7,6-fused tricyclic polyether framework was constructed in a single bromonium-initiated epoxide-opening cascade that incorporates both endo- and exo-selective epoxide openings, each directed by the substitution pattern of the epoxide (methyl groups). This study thus demonstrates the feasibility of a possible biogenesis.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 131 34  شماره 

صفحات  -

تاریخ انتشار 2009